expands: Expanding Ploidy and Allele-Frequency on Nested Subpopulations

Expanding Ploidy and Allele Frequency on Nested Subpopulations (expands) characterizes coexisting subpopulations in a single tumor sample using copy number and allele frequencies derived from exome- or whole genome sequencing input data (<http://www.ncbi.nlm.nih.gov/pubmed/24177718>). The model detects coexisting genotypes by leveraging run-specific tradeoffs between depth of coverage and breadth of coverage. This package predicts the number of clonal expansions, the size of the resulting subpopulations in the tumor bulk, the mutations specific to each subpopulation, tumor purity and phylogeny. The main function runExPANdS() provides the complete functionality needed to predict coexisting subpopulations from single nucleotide variations (SNVs) and associated copy numbers. The robustness of subpopulation predictions increases with the number of mutations provided. It is recommended that at least 200 mutations are used as input to obtain stable results. Updates in version 2.1 include: (i) new parameter ploidy in runExPANdS.R allows specification of non-diploid background ploidies (e.g. for near-triploid cell lines); (ii) parallel computing option is available. Further documentation and FAQ available at <http://dna-discovery.stanford.edu/software/expands>.

Version: 2.1.2
Depends: R (≥ 2.10)
Imports: flexclust, plyr, RColorBrewer, gplots, NbClust, moments (≥ 0.13), rJava (≥ 0.5-0), flexmix (≥ 2.3), matlab (≥ 0.8.9), ape (≥ 3.2), commonsMath (≥ 1.1), parallel
Suggests: phylobase (≥ 0.6.8)
Published: 2018-06-30
Author: Noemi Andor
Maintainer: Noemi Andor <expands.r at gmail.com>
License: GPL-2
URL: http://dna-discovery.stanford.edu/software/expands, https://github.com/noemiandor/expands, https://groups.google.com/d/forum/expands
NeedsCompilation: no
SystemRequirements: Java (>= 5.0)
Materials: NEWS
CRAN checks: expands results

Downloads:

Reference manual: expands.pdf
Vignettes: expands
Package source: expands_2.1.2.tar.gz
Windows binaries: r-devel: expands_2.1.2.zip, r-release: expands_2.1.2.zip, r-oldrel: expands_2.1.2.zip
OS X binaries: r-release: expands_2.1.2.tgz, r-oldrel: expands_2.1.2.tgz
Old sources: expands archive

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